Bren, I know a few people who have taken, or are taking, anti-psychotics to augment an SSRI. As with any drug, side-effects varied, but, like Arran, I think all felt more tired, at least initially. One friend did experience mild hallucinations, but I'm not sure if he was on Risperidone or Sulpiride. Anyway, no harm was done, he was just taken off the drug and the hallucinations stopped.
I found this article on-line which I thought you might be interested in. I am even considering this option for myself, because I need something to help the OCD and depression and it does appear to have positive results.
Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study
Risperidone, an atypical neuroleptic, has been proposed for augmentation strategies in resistant obsessive-compulsive disorder (OCD). We report the results of an open-label trial on the use of the combination of serotonin reuptake inhibitors (SRIs) with risperidone in 20 refractory OCD outpatients. All patients had been suffering from OCD, according to DSM-IV criteria, for at least 2 years and had various comorbid disorders. All had been treated with an SRI at adequate dosages for at least 6 months, but had failed to respond. Therefore, risperidone was added and the dosage titrated up to the mean dose of 3 mg/day over 8 weeks. After 2 months of this regimen, all patients had shown a reduction in obsessive-compulsive symptoms, as assessed by the decrease in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) total score, particularly those with a lifetime comorbidity with bipolar disorder; only three patients reported mild sedation and postural hypotension, two mild extrapyramidal side-effects (tremors and akatysia) and two an increased appetite. All these effects were well tolerated and no patient halted the treatment. The addition of risperidone would appear to be a useful strategy for augmenting SRI effectiveness in refractory OCD patients.
Pfanner C, Marazziti D, Dell'Osso L, Presta S, Gemignani A, Milanfranchi A, Cassano GB.
Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy.
Hope this is of some help. Tricia x
Fri Jun 26 2009 13:56:25
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